NCTF 135 HA is a multi-ingredient solution injected into the skin as a skin rejuvenation treatment. At our clinic in Nişantaşı, Istanbul, it is known as “Paris Işıltısı” (Paris Glow). NCTF stands for “New Cellular Treatment Factor”: it combines hyaluronic acid with the vitamins, minerals, coenzymes, amino acids and nucleic acids that cells need to repair themselves.

With age, the cells’ repair processes slow down. The skin loses moisture and elasticity and starts to look dull. NCTF 135 aims to support these slowed repair processes. When injected into the middle layer of the skin (the dermis), it helps support collagen and elastin production and the skin’s ability to hold water.

In this sense, NCTF 135 is a type of mesotherapy, often called a skin booster. Its aim is not to change your facial features but to improve skin quality for a healthier, brighter look.

Daily habits such as moisturizing, sun protection, balanced nutrition, enough water and good sleep remain the foundation; NCTF 135 supports it from within.

NCTF 135 HA contains 59 active ingredients that benefit the skin. They fall into these main groups:

• Hyaluronic acid: Hydrates the skin and supports its renewal.
• Vitamins: Support collagen production and help protect against free radicals.
• Amino acids: Help build support proteins such as elastin and collagen.
• Coenzymes and nucleic acids: Support metabolic processes in the cells.
• Minerals: Contribute to balance in cell metabolism.
• Glutathione and antioxidants: Help limit cell damage by reducing the effect of free radicals.

Together, once in the dermis, the goals are to support collagen and elastin production, increase water retention and slow pigment formation. The antioxidants may also help reduce visible wear from everyday factors such as sun and pollution.

Besides the face, NCTF 135 can be used on many areas where the skin is thin and delicate:

• Face: For dullness, dehydration and fine lines.
• Under the eyes: For dryness and fine lines in the thin skin around the eyes.
• Neck and décolleté: For skin that thins and develops lines with age. See neck, décolleté and hand treatments.
• Arms: For arm skin that is starting to lose elasticity.

The under-eye area is one of the most asked-about uses of NCTF 135. Here the aim is to improve hydration and freshness in the thin skin. If there is a marked hollow or dark circles, other options within under-eye treatments may also be considered.

It can be used for women and men with early wrinkles, reduced elasticity, dryness or dullness. It can be done in any season and planned for different age groups. It may also be a preventive option for people with signs of sun damage who want to maintain overall skin quality. For other skin-quality treatments with a similar aim, see youth and collagen injections.

Before treatment, your skin is examined and the areas to treat are decided. Stopping aspirin, high-dose omega-3, vitamin E and other medicines or supplements that may increase bleeding for a few days beforehand, after checking with your doctor, reduces the risk of bruising. Please come without makeup.

The treatment follows these steps:

1. The area is cleansed and, if needed, a numbing cream is applied.
2. The NCTF 135 HA solution is injected in small amounts into the middle layer of the skin with very fine needles.
3. The area is cleaned and a soothing product is applied.

The treatment is quick and does not keep you from daily life. Small bumps at the injection points usually disappear within a few hours. In thin-skinned areas such as under the eyes, mild swelling and small bruises may last a few days. NCTF 135 can also be combined with device-based skin treatments. It must be performed by a doctor.

NCTF 135 is usually planned as a course of about 5 sessions in three phases: initiation, repair and balance. In the protocol frequently used at our clinic, the first 3 sessions are 15 days apart and the next 2 are one month apart. The number and spacing of sessions are set by your doctor based on your skin.

The effects begin shortly after injection and become more visible within a few days. By the end of the course, the aim is improved skin quality and softer fine lines. Keeping to the schedule matters.

NCTF 135 is not a lasting fix. Because skin aging continues, regular maintenance helps the results last longer. Two maintenance sessions a year are recommended. How long the effect lasts varies from person to person, depending on age, skin type, sun protection and lifestyle.